Article

Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions

2025-03-11

Abstract excerpt

Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic processes in the human brain that allow for rapid expansion, but contribute to vulnerability to neurodevelopmental disorders, remain largely unexplored. We performed a variety of metabolic assays in primary tissue and s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25734482-d4cb-521e-a699-0810dcedf8e2
DOI: 10.1101/2025.03.10.642470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate TransitionsDOI 10.1101/2025.03.10.642470Read

Glucose and Oxygen Metabolism Coordinate Human Cortical Developmental DecisionsSemantic proximity Read

Mapping energy metabolism systems in the human brainSemantic proximity Read

Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental DisordersSemantic proximity Read

Astrocytes Drive Divergent Metabolic Gene Expression in Humans and ChimpanzeesSemantic proximity Read

Astrocytes drive divergent metabolic gene expression in humans and chimpanzeesSemantic proximity Read

Approaches to investigating metabolism in human neurodevelopment using organoids: insights from intestinal and cancer studiesSemantic proximity Read

A Role for Astrocyte Metabolism in Species-Specific Neuronal DevelopmentSemantic proximity Read

Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2-deficient murine astrocytesSemantic proximity Read

Genetic regulators of neuronal survival across metabolic environmentsSemantic proximity Read

Metabolic Rewiring and Altered Glial Differentiation in an iPSC-Derived Astrocytes Model Derived From a Nonketotic Hyperglycinemia PatientSemantic proximity Read

HPDL is critical in human cortical development via regulation of mitochondrial functional propertiesSemantic proximity Read

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesisSemantic proximity Read