Article

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats

2022-04-05

Abstract excerpt

Insulin-resistant brain state is proposed to be the early sign of Alzheimer’s disease(AD), which can be studied in intracerebroventricular streptozotocin (ICV-STZ) rodent model. ICV-STZ is reported to induce sporadic AD with the majority of the disease hallmarks as phenotype. On the other hand, Available experimental evidence has used varying doses of STZ (<1 to 3mg/kg) and studied its effect for different study d...

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Literature Corpus work: f6b2e125-cb60-5bd7-a86a-6d400bf4a8af
DOI: 10.1101/2022.04.04.486747

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