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Article

Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Plaschke Konstanze, Kopitz Juergen, Siegelin Markus, Schliebs Reinhard, Salkovic-Petrisic Melita, Riederer Peter, Hoyer Siegfried

Abstract excerpt

For studying rare hereditary Alzheimer's disease (AD), transgenic (Tg) animal models overexpressing amyloid-beta protein precursor (AbetaPP) followed by increased amyloid-beta (Abeta) formation are used. In contrast, sporadic AD has been proposed to start with an insulin-resistant brain state (IRBS).We investigated the effect of IRBS induced by intracerebroventricularly (icv) administered streptozotocin (STZ) on...

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Source

Identifiers

PMID: 20110613
DOI: 10.3233/JAD-2010-1270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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