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Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer’s disease by repressing FoxO1 gene expression

26 Jul 2025

Abstract excerpt

Impaired brain insulin signaling is a risk factor for the pathogenesis of Alzheimer's disease (AD). FoxO1 and HMGA1 transcription factors are involved in the pathogenesis of both type 2 diabetes (T2D) and Alzheimer's disease (AD). This study aimed to assess the effect of vanadyl sulfate (VS) on impaired memory and hippocampal FoxO1 and HMGA1 RNA expression in sporadic AD (sAD) model in rats. Thirty-two male...

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PMID: 40715349
DOI: 10.1038/s41598-025-12426-4

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