Temporal dynamics of cognitive and non-cognitive behavioral phenotypes and early redox alterations in the intracerebroventricular streptozotocin-rat model of sporadic Alzheimer's disease.

Abstract excerpt

The intracerebroventricular streptozotocin (ICV-STZ) model mimics sporadic Alzheimer's disease (sAD), yet its early multi-domain behavioral progression and underlying mechanisms remain poorly characterized. This study provides the first cross-sectional temporal profiling integrating behavioral and redox phenotypes, uncovering novel dynamics that enhance the model's translational value for prodromal sAD. Male...

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