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A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes

10 Oct 2023

Abstract excerpt

Global eradication of poliovirus remains elusive, and it is critical to develop next generation vaccines and antivirals. In support of this goal, we map the epitope of human monoclonal antibody 9H2 which is able to neutralize the three serotypes of poliovirus. Using cryo-EM we solve the near-atomic structures of 9H2 fragments (Fab) bound to capsids of poliovirus serotypes 1, 2, and 3. The Fab-virus complexes show...

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PMID: 37816742
DOI: 10.1038/s41467-023-41052-9

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