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Article

Somatic Hypermutation and Framework Mutations of Variable Region Contribute to Anti-Zika Virus-Specific Monoclonal Antibody Binding and Function.

Journal of virology - 8 Jun 2022

Tsuji Isamu, Vang Fue, Dominguez David, Karwal Lovkesh, Sanjali Ankita, Livengood Jill A, Davidson Edgar, Fouch Mallorie E, Doranz Benjamin J, Das Subash C, Dean Hansi J

Abstract excerpt

Zika virus (ZIKV) is a global public health concern due to its ability to cause congenital Zika syndrome and lack of approved vaccine, therapeutic, or other control measures. We discovered eight novel rabbit monoclonal antibodies (MAbs) that bind to distinct ZIKV envelope protein epitopes. The majority of the MAbs were ZIKV specific and targeted the lateral ridge of the envelope (E) protein domain III, while the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35575481
DOI: 10.1128/jvi.00071-22
PMCID: PMC9175631

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