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Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody

1 Mar 2019

Abstract excerpt

We previously reported a human monoclonal antibody, ZK2B10, capable of protection against Zika virus (ZIKV) infection and microcephaly in developing mouse embryos. Here, we report the structural features and mechanism of action of ZK2B10. The crystal structure at a resolution of 2.32 Å revealed that the epitope is located on the lateral ridge of DIII of the envelope glycoprotein. Cryo-EM structure with mature...

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PMID: 30893607
DOI: 10.1016/j.celrep.2019.02.062

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