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A human antibody against Zika virus crosslinks the E protein to prevent infection

16 Mar 2017

Abstract excerpt

The recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. Neutralizing antibodies present a possible therapeutic approach to prevent and control ZIKV infection. Here we present a 6.2 Å resolution three-dimensional cryo-electron microscopy (cryoEM) structure of an infectious...

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PMID: 28300075
DOI: 10.1038/ncomms14722

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