Article

Senotherapeutic potential against xeroderma pigmentosum

2025-05-23

Abstract excerpt

Xeroderma pigmentosum (XP) is an inherited photoaging syndrome caused by mutations in genes involved in the nucleotide excision repair (NER) pathway. XP patients exhibit hypersensitivity to ultraviolet (UV) radiation, leading to accelerated skin aging and requiring lifelong sun avoidance. Here, we demonstrate that UV-induced DNA damage triggers cellular senescence and up-regulates senescence-associated secretory p...

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Literature Corpus work: f6b0b199-8039-574e-8e40-b3ef4ee6e869
DOI: 10.1101/2025.05.22.655641

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