Article

Synthetic rescue of XPC phenotype via PIK3C3 downregulation

2023-09-18

Abstract excerpt

<title>Abstract</title> <p>Xeroderma Pigmentosum C is a dermal hereditary disease. It is caused by a mutation in the DNA damage recognition protein XPC that belongs to the Nucleotide excision repair pathway. XPC patients exhibit a photosensitive phenotype and fail to repair UV induced DNA lesions leading to their accumulation and ultimate conversion to mutations and carcinomas. In an attempt to normalize this phe...

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Literature Corpus work: a7cfdf3d-d3b1-5553-9dae-61535a4ae7c6
DOI: 10.21203/rs.3.rs-3293829/v1

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