Article

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

2023-10-02

Abstract excerpt

Malignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cancer cell fates after treatment including cell death and senescence. Senescent cells can be eliminated using senolytic drugs and we hypothesize that the targeted elimination of therapy-induced senescent melanoma cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70d8e091-b14e-5eda-80c9-7aed02962037
DOI: 10.1101/2023.10.01.560354

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cellsDOI 10.1101/2023.10.01.560354Read

The Convergence of Senescence and Ferroptosis Amplifies DNA Damage and Triggers Apoptosis in Patient-Derived Melanoma ModelsSemantic proximity Read

Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cellsSemantic proximity Read

DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor SensitivitySemantic proximity Read

A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanomaSemantic proximity Read

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor GrowthSemantic proximity Read

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regressionSemantic proximity Read

Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent CellsSemantic proximity Read

Apoptosis-coupled senescence causes cancer cell senotherapySemantic proximity Read

Melanomagenesis: Overcoming the barrier of melanocyte senescenceSemantic proximity Read

Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and OpportunitiesSemantic proximity Read

The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated MelanomaSemantic proximity Read

Palbociclib CDK4/6- and Crizotinib MET/ALK/ROS1-inhibitors Synergize to Enhance Senescence and Immune Recognition in Melanoma Cells Independently of <i>BRAF</i> / <i>NRAS</i> StatusSemantic proximity Read