Article

Synthetic rescue of XPC phenotype via PIK3C3 downregulation

2023-08-09

Abstract excerpt

Xeroderma Pigmentosum C is a dermal hereditary disease. It is caused by a mutation in the DNA damage recognition protein XPC that belongs to the Nucleotide excision repair pathway. XPC patients exhibit a photosensitive phenotype and fail to repair UV induced DNA lesions leading to their accumulation and ultimate conversion to mutations and carcinomas. In an attempt to normalize this phenotype, we screened a librar...

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Literature Corpus work: 12a364c6-bc1a-55aa-8c5a-90fbf6f1e576
DOI: 10.1101/2023.08.08.552431

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