Article

O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer

2018-06-12

Abstract excerpt

Pancreatic cancer is among the 3 rd leading cause of cancer related deaths in the United States along with a 5-year survival rate of 7%. The aggressive biology of the disease is responsible for such dismal outcome and is manifested by an increase in self-renewal capacity of the cancer cells, which leads to an increased rate of tumor-recurrence, contributing to poor prognosis. Transcription factor SOX2 maintains a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f69526a6-12a1-515f-8675-58b8101e9931
DOI: 10.1101/345223

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancerDOI 10.1101/345223Read

O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells.Semantic proximity Read

Pan-Cancer Analysis Reveals SOX2 as a Promising Prognostic and Immunotherapeutic Biomarker Across Various Cancer Types, Including Pancreatic CancerSemantic proximity Read

BAZ2A-SUV39H1-SMAD2/3-OCT4 regulates stemness, cell cycle exit and chemoresistance in pancreatic ductal adenocarcinomaSemantic proximity Read

Embryonic stem cell factors and pancreatic cancerSemantic proximity Read

GALNT2 sustains glioma stem cells by promoting CD44 expressionSemantic proximity Read

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cellsSemantic proximity Read

Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate ConversionSemantic proximity Read

O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.Semantic proximity Read

An O-GlcNAc transferase pathogenic variant that affects pluripotent stem cell self-renewalSemantic proximity Read

Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2Semantic proximity Read

SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics studySemantic proximity Read

Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53Semantic proximity Read