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Article

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

5 Aug 2013

Abstract excerpt

SOX2 (Sex-determining region Y (SRY)-Box2) has important functions during embryonic development and is involved in cancer stem cell (CSC) maintenance, in which it impairs cell growth and tumorigenicity. However, the function of SOX2 in pancreatic cancer cells is unclear. The objective of this study was to analyze SOX2 expression in human pancreatic tumors and determine the role of SOX2 in pancreatic cancer cells...

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Identifiers

PMID: 23917223
DOI: 10.1038/oncsis.2013.23

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