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Article

O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells.

Experimental & molecular medicine - 1 Nov 2021

Kim Dong Keon, Lee Jang-Seok, Lee Eun Young, Jang Hansol, Han Suji, Kim Hee Yeon, Hwang In-Young, Choi Ji-Woong, Shin Hyun Mu, You Hye Jin, Youn Hong-Duk, Jang Hyonchol

Abstract excerpt

Sox2 is a core transcription factor in embryonic stem cells (ESCs), and O-GlcNAcylation is a type of post-translational modification of nuclear-cytoplasmic proteins. Although both factors play important roles in the maintenance and differentiation of ESCs and the serine 248 (S248) and threonine 258 (T258) residues of Sox2 are modified by O-GlcNAcylation, the function of Sox2 O-GlcNAcylation is unclear. Here, we...

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Share to Cell Self Renewal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34819616
DOI: 10.1038/s12276-021-00707-7
PMCID: PMC8639819

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