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Article

Diversity and impact of rare variants in genes encoding the platelet G protein-coupled receptors.

Thrombosis and haemostasis - 1 Apr 2015

Jones Matthew L, Norman Jane E, Morgan Neil V, Mundell Stuart J, Lordkipanidzé Marie, Lowe Gillian C, Daly Martina E, Simpson Michael A, Drake Sian, Watson Steve P, Mumford Andrew D

Abstract excerpt

Platelet responses to activating agonists are influenced by common population variants within or near G protein-coupled receptor (GPCR) genes that affect receptor activity. However, the impact of rare GPCR gene variants is unknown. We describe the rare single nucleotide variants (SNVs) in the coding and splice regions of 18 GPCR genes in 7,595 exomes from the 1,000-genomes and Exome Sequencing Project databases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25567036
DOI: 10.1160/TH14-08-0679
PMCID: PMC4510585

Genes

MAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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