Article

Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABA A receptors by two distinct mechanisms

2022-01-12

Abstract excerpt

<h4>Background: </h4> and Purpose: Many psychotherapeutic drugs, including clozapine, display polypharmacology and act on GABA A receptors. Patients with schizophrenia show alterations in function, structure and molecular composition of the hippocampus, and a recent study demonstrated aberrant levels of hippocampal a5 subunit-containing GABA A receptors. The purpose of this study is to investigate tricyclic comp...

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Literature Corpus work: f68af865-5e99-5a4b-90f4-e6a99c4622f0
DOI: 10.22541/au.161797799.93015888/v3

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