Article

Epigenetically silenced DACT3 promotes tumor growth via affecting Wnt/beta-catenin signaling and supports chidamide plus azacitidine therapy in acute myeloid leukemia

2023-01-09

Abstract excerpt

<h4>Background</h4> DACT gene is a potential Wnt antagonist and tumor suppressor gene. However, the expression of DACT gene in acute myeloid leukemia (AML) and its role are still unknown. <h4>Methods</h4> In this study, we first multidimensionally analyzed the expression of DACT gene in AML through RNA seq, qRT-PCR and Western blotting analysis as well as TCGA database analysis. Then DACT3 was identified as play...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f676d486-c992-5538-8801-981e10c2b20f
DOI: 10.1101/2023.01.09.523194

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetically silenced DACT3 promotes tumor growth via affecting Wnt/beta-catenin signaling and supports chidamide plus azacitidine therapy in acute myeloid leukemiaDOI 10.1101/2023.01.09.523194Read

The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemiaSemantic proximity Read

[Functional role of DNMT3A mutation in acute myeloid leukemia].Semantic proximity Read

Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.Semantic proximity Read

HDAC3 inhibition as a therapeutic strategy in T-cell acute lymphoblastic leukemia via the TYK2-STAT1-BCL2 signaling pathwaySemantic proximity Read

WNT6 affects the prognosis of pediatric acute myeloid leukemia through regulation of Wnt signaling pathway activitySemantic proximity Read

Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylationSemantic proximity Read

Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemiaSemantic proximity Read

DNMT3A mutations in Chinese childhood acute myeloid leukemia.Semantic proximity Read

[Analysis of DNMT3a mutation in childhood acute myeloid leukemia].Semantic proximity Read

Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.Semantic proximity Read

HDAC inhibitor chidamide overcomes drug resistance in chronic myeloid leukemia with the T315i mutation through the Akt-autophagy pathway.Semantic proximity Read

Upregulated expression of DACT1 and CYCLIN D1 have co-expression positive correlation in patients with colorectal cancerSemantic proximity Read