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Article

Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.

Epigenetics - 1 Apr 2013

Zhang Xiaomei, Yang Yunsheng, Liu Xuefeng, Herman James G, Brock Malcolm V, Licchesi Julien D F, Yue Wen, Pei Xuetao, Guo Mingzhou

Abstract excerpt

DACT2 (Dapper, Dishevelled-associated antagonist of β-catenin homolog 2) is a member of the DACT family involved in the regulation of embryonic development. Human DACT2 is localized on 6q27, a region of frequent loss of heterozygosity in human cancers. However, the regulation of DACT2 expression and function in hepatocellular carcinoma (HCC) remains unclear. In this study, genetic and epigenetic changes of DACT2...

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Source

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Identifiers

PMID: 23449122
DOI: 10.4161/epi.24113
PMCID: PMC3674046

Genes

DACT2

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