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Article

Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.

The Journal of pathology - 1 Jun 2013

Jia Yan, Yang Yunsheng, Brock Malcolm V, Zhan Qimin, Herman James G, Guo Mingzhou

Abstract excerpt

Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is involved in Xenopus embryonic development. Human DACT2 is localized on chromosome 6q27, a region of frequent loss of heterozygosity (LOH) in human cancers. However, the function and regulation of DACT2 in human lung cancer remain unclear. DNA sequencing, methylation-specific PCR (MSP), semi-quantitative RT-PCR, western blotting, and xenograft...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 6

Share to Gene Knockdown Techniques

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Source

Open in PubMed Open full text

Identifiers

PMID: 22806826
DOI: 10.1002/path.4073
PMCID: PMC4061565

Genes

DACT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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