Effect of maternal folate levels on somatic mutation frequency in the developing colon.

doi:10.1016/s0027-5107(98)00147-x

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Article

Effect of maternal folate levels on somatic mutation frequency in the developing colon.

Mutation research - 31 Aug 1998

Trentin G A, Moody J, Heddle J A

Abstract excerpt

Folic acid deficiency is associated with an increase in chromosomal aberrations in adult rodents and humans. Somatic mutations have a critical role in carcinogenesis. Since most mutations arise during early development, the effect of maternal folic acid levels on the spontaneous mutant frequency...

Topics

Age Factors
Animals
Bacteriophage lambda
Cells, Cultured
Colon
Diet
Female
Folic Acid
Folic Acid Deficiency
Humans
Lac Operon
Male
Mice
Mice, Transgenic
Mutation
Risk Factors
Viral Plaque Assay

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