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Article

Effect of maternal folate levels on somatic mutation frequency in the developing colon.

Mutation research - 31 Aug 1998

Trentin G A, Moody J, Heddle J A

Abstract excerpt

Folic acid deficiency is associated with an increase in chromosomal aberrations in adult rodents and humans. Somatic mutations have a critical role in carcinogenesis. Since most mutations arise during early development, the effect of maternal folic acid levels on the spontaneous mutant frequency in the developing colon was examined using lacZ transgenic mice. No significant difference in mutant frequencies at...

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PMID: 9729293
DOI: 10.1016/s0027-5107(98)00147-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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