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Folic acid deficiency and cancer: mechanisms of DNA instability

1 Jan 1999

Abstract excerpt

Folic acid deficiency in humans has been linked with megaloblastic anaemia, neural tube defects in the neonate, and heart disease. Folate has also been implicated in the development of cancer, especially cancer of the colorectum. There appear to be two principal mechanisms through which low folate status may increase the risk of malignancy. Folate deficiency, by reducing intracellular S-adenosylmethionine (SAM),...

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PMID: 10746348
DOI: 10.1258/0007142991902646

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