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Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn’s disease

2023-03-22

Abstract excerpt

<h4>Background and Aims</h4> Anti-TNF treatment failure in patients with inflammatory bowel disease (IBD) is common and frequently related to low drug concentrations. In order to identify patients who may benefit from dose optimisation at the outset of anti-TNF therapy, we sought to define epigenetic biomarkers in whole blood at baseline associated with anti-TNF drug concentrations at week 14. <h4>Methods</h4> DNA...

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Literature Corpus work
f6690a20-ddac-5b55-b15b-f32c7e67f4c7
DOI
10.1101/2023.03.22.23287574
Open publication

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Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn’s diseaseDOI 10.1101/2023.03.22.23287574
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