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Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis

20 Aug 2019

Abstract excerpt

OBJECTIVES: Identifying blood-based biomarkers that predict treatment response in RA is a clinical priority. We investigated differential DNA methylation as a candidate biomarker of response for the first-line drug used in RA, MTX. METHODS: DNA methylation was measured in DNA samples from individuals recruited to the Rheumatoid Arthritis Medication Study. Differentially methylated positions were compared between...

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PMID: 31598719
DOI: 10.1093/rheumatology/kez411

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