Article

Genetic modification of primary human B cells generates translationally-relevant models of high-grade lymphoma

2019-04-26

Abstract excerpt

Sequencing studies of Diffuse Large B Cell Lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis, either individually or in combination. Existing strategies to address this problem predominantly utilize cell lines, which are limited by their initial characteristics and subsequent adaptions to pro...

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Literature Corpus work: 2b0fd417-4b5a-54b9-8454-fba5b5eedc40
DOI: 10.1101/618835

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