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Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy

16 Apr 2022

Abstract excerpt

Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2) is a newly emerging immune checkpoint that belongs to B7 family. HHLA2 has a co-stimulatory receptor transmembrane and immunoglobulin domain containing 2 (TMIGD2) and a newly discovered co-inhibitory receptor killer cell Ig-like receptor, three Ig domains, and long cytoplasmic tail (KIR3DL3), which endows it with both immunostimulant and...

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PMID: 35439678
DOI: 10.1016/j.ebiom.2022.103987

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