Article

RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy

2025-10-12

Abstract excerpt

Tumor-infiltrating lymphocytes (TILs) are a promising autologous cell therapy to treat solid tumors. TILs are manufactured by expanding and reinfusing tumor-reactive T cells from tumor biopsies. Efficacy of TIL therapies has been limited by the heterogeneity of expanded TIL products and the high prevalence of dysfunctional exhausted CD8+ T cells (T EX ). While a subset of CD8+ TILs co-expressing CD103 and CD39 ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9d72b65-4c96-5b47-b602-9bca2fab969b
DOI: 10.1101/2025.10.11.681829

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell TherapyDOI 10.1101/2025.10.11.681829Read

RelB Upregulates PD-L1 and Exacerbates Prostate Cancer Immune EvasionSemantic proximity Read

Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis.Semantic proximity Read

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.Semantic proximity Read

The Presence of CD11c+ B Cells with Potent Effector Memory Phenotype in Lung Adenocarcinoma Correlates with Overall Patient Survival.Semantic proximity Read

Spontaneous EBV-positive B cell line from rectal tumor: characterization, interaction with autologous tumor-infiltrating T lymphocytes, comparison with B lymphoma cell linesSemantic proximity Read

Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignanciesSemantic proximity Read

CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human CancerSemantic proximity Read

Phenotypic Characterization and Prognostic Impact of CD103+ Tissue-Resident Memory T Cells in Diffuse Large B-cell Lymphoma.Semantic proximity Read

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B-cell lymphomaSemantic proximity Read

BCL11B targeting in tumor CD8 <sup>+</sup> T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicitySemantic proximity Read

Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer ImmunotherapySemantic proximity Read

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profileSemantic proximity Read