Genome-wide protective response used by group A <i>Streptococcus</i> to evade destruction by human polymorphonuclear leukocytes

doi:10.1073/pnas.0337370100

Article

Genome-wide protective response used by group A <i>Streptococcus</i> to evade destruction by human polymorphonuclear leukocytes

6 Feb 2003

Abstract excerpt

Group A Streptococcus (GAS) evades polymorphonuclear leukocyte (PMN) phagocytosis and killing to cause human disease, including pharyngitis and necrotizing fasciitis (flesh-eating syndrome). We show that GAS genes differentially regulated during phagocytic interaction with human PMNs comprise a global pathogen-protective response to innate immunity. GAS prophage genes and genes involved in virulence, oxidative...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.