Article

Direct long read visualization reveals metabolic interplay between two antimalarial drug targets

2023-02-13

Abstract excerpt

Increases in the copy number of large genomic regions, termed genome amplification, are an important adaptive strategy for malaria parasites. Numerous amplifications across the Plasmodium falciparum genome contribute directly to drug resistance or impact the fitness of this protozoan parasite. During the characterization of parasite lines with amplifications of the dihydroorotate dehydrogenase ( DHODH ) gene, w...

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Literature Corpus work: f610a8ec-0eb6-5663-83b6-8751b6d69841
DOI: 10.1101/2023.02.13.528367

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