Article
A systematic map of genetic variation in Plasmodium falciparum.
PLoS pathogens - 1 Jun 2006
Kidgell Claire, Volkman Sarah K, Daily Johanna, Borevitz Justin O, Plouffe David, Zhou Yingyao, Johnson Jeffrey R, Le Roch Karine, Sarr Ousmane, Ndir Omar, Mboup Soulyemane, Batalov Serge, Wirth Dyann F, Winzeler Elizabeth A
Abstract excerpt
Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the appropriate use of antimalarial drugs. By performing a full-genome scan of allelic variability in 14 field and laboratory strains of P. falciparum, we...
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