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Article

Adaptive copy number evolution in malaria parasites.

PLoS genetics - 1 Oct 2008

Nair Shalini, Miller Becky, Barends Marion, Jaidee Anchalee, Patel Jigar, Mayxay Mayfong, Newton Paul, Nosten François, Ferdig Michael T, Anderson Tim J C

Abstract excerpt

Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP. We provide compelling ev...

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Identifiers

PMID: 18974876
DOI: 10.1371/journal.pgen.1000243
PMCID: PMC2570623

Genes

CNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18974876-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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