Article

VEGFA+ macrophages promote the growth and metastasis of intrahepatic cholangiocarcinoma via OSM and THBS1 signaling

2025-10-04

Abstract excerpt

Tumor-associated macrophages (TAMs) are abundant in intrahepatic cholangiocarcinoma (ICC) and correlate with poor prognosis, but their non-immunosuppressive roles remain unclear. This study aimed to define TAM transcriptional heterogeneity and map their interactions with ICC cells that promote malignancy beyond immune suppression. Single-cell and spatial transcriptome analysis with mouse and human ICC tissues reve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6033553-9f7d-5b26-81b3-6ed0042d58b9
DOI: 10.1101/2025.10.02.679723

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VEGFA+ macrophages promote the growth and metastasis of intrahepatic cholangiocarcinoma via OSM and THBS1 signalingDOI 10.1101/2025.10.02.679723Read

Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic targetSemantic proximity Read

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patientsSemantic proximity Read

Macrophages-aPKCι-CCL5 Feedback Loop Modulates the Progression and Chemoresistance in CholangiocarcinomaSemantic proximity Read

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinomaSemantic proximity Read

Spatial and Single-Cell Transcriptomics Decipher the Crosstalk Environment of <i>DEFB1</i> <sup>+</sup> Cancer Cells and <i>IFI30</i> <sup>+</sup> Macrophages in Intrahepatic CholangiocarcinomaSemantic proximity Read

Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma.Semantic proximity Read

Therapy-induced senescent-like cancer cells drive macrophage-mediated immunosuppression in cholangiocarcinomaSemantic proximity Read

Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinomaSemantic proximity Read

Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing–Assisted Multiomics AnalysisSemantic proximity Read

Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progressionSemantic proximity Read

Spatiotemporal Mapping of Tertiary Lymphoid Structure Heterogeneity Shapes Immune Niches and Clinical Outcomes in Intrahepatic CholangiocarcinomaSemantic proximity Read

Heterogeneity of Cholangiocarcinoma Immune BiologySemantic proximity Read