Article

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients

2024-02-07

Abstract excerpt

<h4>Background and aims</h4> Cholangiocarcinoma (CCA) is a deadly disease, and this cancer entity is characterized by an abundant stroma. The tumor microenvironment (TME) plays an important role in aggressive behavior and poor response to therapeutics; however, underlying pathways are unknown. <h4>Methods</h4> To fill this gap, we used multiplexed immunohistochemistry, high-dimensional phenotyping, and transcrip...

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Literature Corpus work: 0e2dec7a-1956-579d-bd94-3e0df0fafcf3
DOI: 10.1101/2024.02.03.578669

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