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Article

Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma.

Journal of translational medicine - 19 Oct 2024

Jiang Hao, Gao Biao, Meng Zihe, Wang Yafei, Jiao Tianyu, Li Junfeng, Li Xuerui, Cao Yinbiao, Zhang Xianzhou, Li Chonghui, Lu Shichun

Abstract excerpt

This study aims to investigate the interplay between tumor-associated endothelial cells (TECs) and immune cells within the tumor microenvironment (TME) and its impact on tumor prognosis. We conducted single-cell RNA sequencing (scRNA-seq) of tumor, normal, and lymph node tissues obtained from intrahepatic cholangiocarcinoma (ICC) patients to reveal the role of TECs in tumor angiogenesis and their significant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39427165
DOI: 10.1186/s12967-024-05750-2
PMCID: PMC11490089

Genes

TEC
CXCL12
CXCR4
BAP1
CD4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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