Article

FLT3 inhibition upregulates OCT4/NANOG to promote proliferation and TKI resistance of FLT3-ITD+ acute myeloid leukemia

2024-04-29

Abstract excerpt

<title>Abstract</title> <p><italic>Background: </italic>Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due to the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. Although FLT3 inhibitors show encouraging outcomes in treatment, they fail to eliminate leukemia stem cells, the origin of persistent and resistant lesions. Exploration of the mechanism...

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Literature Corpus work: f5f8e4cd-2414-52d6-9518-d878ba33131c
DOI: 10.21203/rs.3.rs-4310376/v1

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