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Article

Germ line polymorphisms of genes involved in pluripotency transcription factors predict efficacy of cetuximab in metastatic colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2021

Arai Hiroyuki, Millstein Joshua, Loupakis Fotios, Stintzing Sebastian, Wang Jingyuan, Battaglin Francesca, Kawanishi Natsuko, Jayachandran Priya, Soni Shivani, Zhang Wu, Mumenthaler Shannon M, Cremolini Chiara, Heinemann Volker, Falcone Alfredo, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) are primarily maintained by a network of pluripotency transcription factors (PTFs). Given a close relationship of CSC regulation with epidermal growth factor receptor and vascular endothelial growth factor signalling, we investigated whether single-nucleotide polymorphisms (SNPs) in PTF genes are related to the efficacy of cetuximab and/or bevacizumab in patients with...

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Identifiers

PMID: 33901792
DOI: 10.1016/j.ejca.2021.03.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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