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Regulation of NANOG in cancer cells

27 May 2015

Abstract excerpt

As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self-renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates with poor survival in cancer patients. Of interest, many studies suggest that NANOG enhances the defined characteristics of cancer stem cells and may thus...

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PMID: 26013997
DOI: 10.1002/mc.22340

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