Article
Beyond corticosteroids: future prospects in the management of inflammation in COPD.
European respiratory review : an official journal of the European Respiratory Society - 1 Sept 2011
Roche N, Marthan R, Berger P, Chambellan A, Chanez P, Aguilaniu B, Brillet P-Y, Burgel P-R, Chaouat A, Devillier P, Escamilla R, Louis R, Mal H, Muir J-F, Pérez T, Similowski T, Wallaert B, Aubier M
Abstract excerpt
Inflammation plays a central role in the pathophysiology of chronic obstructive pulmonary disease (COPD). Exposure to cigarette smoke induces the recruitment of inflammatory cells in the airways and stimulates innate and adaptive immune mechanisms. Airway inflammation is involved in increased bronchial wall thickness, increased bronchial smooth muscle tone, mucus hypersecretion and loss of parenchymal elastic...
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