Article

Evaluating xenograft mouse models for preclinical assessment of adoptive T cell transfer

2025-05-30

Abstract excerpt

<title>Abstract</title> <p>Humanized mouse models are crucial for preclinical testing of adoptive cell transfer (ACT) strategies in cancer immunotherapy. A key challenge is identifying models that enable efficient human T cell engraftment while minimizing graft-versus-host disease (GVHD), which hinders long-term assessment of T cell functionality. The immunodeficient NOD/SCID/IL-2Rγnull (NOG) mouse strain with tr...

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Literature Corpus work: f5410f80-3c90-5709-8738-6e25c1e239fb
DOI: 10.21203/rs.3.rs-6528016/v1

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