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Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation

13 Dec 2013

Abstract excerpt

Hematopoietic stem cell transplantation from a healthy donor (allo-HSCT) represents the most potent form of cellular adoptive immunotherapy to treat malignancies. In allo-HSCT, donor T cells are double edge-swords: highly potent against residual tumor cells, but potentially highly toxic, and responsible for graft versus host disease (GVHD), a major clinical complication of transplantation. Gene transfer...

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PMID: 24329796
DOI: 10.1111/imr.12130

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