Back to search

Article

A DNA Replication-Independent Function of the pre-Replication Complex during Cell Invasion in <i>C. elegans</i>

2021-06-11

Abstract excerpt

Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. A screen of C. elegans orthologs of genes over-expressed in invasive human melanoma cells has identified several components of the conserved DNA pre-replication complex (pre-RC) as positive regulators of anchor cell (AC) invasion. The pre-RC functions cell-autonomously in the G1-arrested AC to promote in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f5379ee2-b3b9-5964-a9c7-6b773489b0e0
DOI
10.1101/2021.06.10.447853
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A DNA Replication-Independent Function of the pre-Replication Complex during Cell Invasion in <i>C. elegans</i>DOI 10.1101/2021.06.10.447853
The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion <i>in vivo</i>Semantic proximity
Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in <i>C. elegans</i>Semantic proximity
A developmental gene regulatory network for invasive differentiation of the <i>C. elegans</i> anchor cellSemantic proximity
The <i>C. elegans</i> homolog of the <i>Evi1</i> proto-oncogene, <i>egl-43</i> , coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasionSemantic proximity
The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.Semantic proximity
Cancer models in Caenorhabditis elegansSemantic proximity
A Meier-Gorlin Syndrome Mutation in Orc4 Causes Tissue-Specific DNA Replication Defects in <i>Drosophila melanogaster</i>Semantic proximity
A reevaluation of the relationship between EGL-43 (EVI1/MECOM) and LIN-12 (Notch) during <i>C. elegans</i> anchor cell invasionSemantic proximity
Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.Semantic proximity
CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans.Semantic proximity
The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.Semantic proximity
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.Semantic proximity
Select a neighboring publication to make it the new centre.