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Article

Repressor element 1–silencing transcription factor drives the development of chronic pain states

14 Jun 2019

Abstract excerpt

Chronic pain is an unmet clinical problem with vast individual, societal, and economic impact. Pathologic activity of the peripheral somatosensory afferents is one of the major drivers of chronic pain. This overexcitable state of somatosensory neurons is, in part, produced by the dysregulation of genes controlling neuronal excitability. Despite intense research, a unifying theory behind neuropathic remodelling is...

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PMID: 31206463
DOI: 10.1097/j.pain.0000000000001633

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