Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer’s Disease

Abstract excerpt

Plasma pTau217, an emerging Alzheimer’s disease (AD) biomarker, may reflect a synaptic response to β-amyloid (Aβ) plaques before cortical tangle formation, but its broader biological correlates remain unclear. We sought to identify associations between whole blood gene expression and plasma pTau217, and to determine whether APOE ε4, sex, and neocortical Aβ-PET modify these associations in 724 participants from th...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Apolipoproteins E
• Brain
• Gene Expression Profiling
• Sex Characteristics
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

f5287cf6-6d2f-5ab6-8d73-a235d9ced588

DOI

10.1101/2025.11.21.689770