Back to search

Article

A novel mRNA Lipid Nanoparticle Therapy Improves Heart Failure Phenotype and Suppresses Endothelial-Mesenchymal Transition In Vitro

2026-05-26

Abstract excerpt

<h4>Objectives</h4> To evaluate the therapeutic potential of BMP-7 mRNA-lipid nanoparticle formulation in attenuating cardiac fibrosis and improving function in non-ischemic heart failure, and to assess its impact on endothelial phenotype and function under pro endothelial-to-mesenchymal transition (EndMT) conditions. <h4>Background</h4> Despite advances in neurohormonal blockade, heart failure (HF) progression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f523d4ba-da5f-5f89-a633-9205c365ecd5
DOI
10.64898/2026.05.22.727265
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel mRNA Lipid Nanoparticle Therapy Improves Heart Failure Phenotype and Suppresses Endothelial-Mesenchymal Transition In VitroDOI 10.64898/2026.05.22.727265
Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery ThereafterSemantic proximity
Recovery from Heart Failure is a Vascular RecoverySemantic proximity
A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts <i>in vivo</i> efficacy for heart transfectionSemantic proximity
Synthetic Cannabidiol Attenuates Heart Failure Progression with Concomitant and Post Injury Administration Through Modulation of Immune and Endothelial to Mesenchymal Transition – Related Remodeling ProgramsSemantic proximity
Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technologySemantic proximity
Targeting <i>Runx</i> 1 protects against heart failure with preserved ejection fractionSemantic proximity
Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking.Semantic proximity
Myocardial and Circulating microRNA Expression Profile and Biomarker Potential in LVAD-Supported End-Stage Heart Failure Patients – a Comprehensive Review and Update of the LiteratureSemantic proximity
Insulin growth-factor 1Ea gene transfer therapy after myocardial infarctionSemantic proximity
Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction ModelSemantic proximity
Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxiaSemantic proximity
miR-31-5p-Modified RAW 264.7 Macrophages Affect Profibrotic Phenotype of Lymphatic Endothelial Cells In Vitro.Semantic proximity
Select a neighboring publication to make it the new centre.