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A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts <i>in vivo</i> efficacy for heart transfection

2025-03-12

Abstract excerpt

Lipid nanoparticle (LNP)/mRNA complexes have tremendous potential for treating cardiac diseases but lack the transfection efficiency required for successful heart therapeutics. A challenge preventing the development of cardiac LNPs is the lack of in vitro screening platforms that maximize transfection and predict efficacy. Here, we demonstrate that a phenotypic cardiac microphysiological system (MPS), constructed...

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Identifiers and source

Literature Corpus work
c06b4ade-34ce-5ca0-8bc6-43aacc2b59b5
DOI
10.1101/2025.03.07.642075
Open publication

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A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts <i>in vivo</i> efficacy for heart transfectionDOI 10.1101/2025.03.07.642075
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