Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia

29 Apr 2025

Abstract excerpt

Myocardial fibrosis (MF) is a common pathological hallmark of cardiovascular diseases, reflecting shared mechanisms in their progression. However, the lack of reliable MF models that accurately mimic its pathogenesis has hindered drug discovery, highlighting the urgent need for more effective therapeutic agents. Herein, a novel contractile three-dimensional (3D) myocardial tissue model integrating cardiomyocytes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Cardiac Fibrosis and Remodeling
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40654352
DOI: 10.1016/j.apsb.2025.04.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxiaPMID 40654352Read ↗

Cardiac fibrosis inhibitor CTPR390 prevents structural and morphological changes in collagen and fibroblasts of engineered human connective tissueSemantic proximity Read ↗

Heart Slice Culture System Reliably Demonstrates Clinical Drug-Related CardiotoxicitySemantic proximity Read ↗

Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cellsSemantic proximity Read ↗

The dual PPAR-α/δ agonist elafibranor attenuates TGF-β <sub>1</sub> -induced cardiac fibrosis through redox-metabolic and bioenergetic reprogramming in human cardiac modelsSemantic proximity Read ↗

ROS-Responsive Core-Shell Microneedles Loaded with Black Phosphorus Nanosheets and Bufalin for Combined Intervention of Oxidative Stress and Cardiac Fibrosis Post Myocardial InfarctionSemantic proximity Read ↗

Transplantation of IPSC-Derived Cardiomyocyte Patches for Ischemic CardiomyopathySemantic proximity Read ↗

Engineering Cardiac Muscle Tissue: A Maturating Field of Research.Semantic proximity Read ↗

Advanced Cardiac Organoid Model for Studying Doxorubicin-Induced CardiotoxicitySemantic proximity Read ↗

Myocardial fibroblast–matrix interactions and potential therapeutic targetsSemantic proximity Read ↗

Decoding mechanosensitive genes in cardiac fibroblasts via 3D hydrogel models of fibrosisSemantic proximity Read ↗

Repurposing Nintedanib for Pathological Cardiac Remodeling and DysfunctionSemantic proximity Read ↗

Revolutionizing cardiac fibrosis treatment: the potential of personalized CAR T-cell therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.