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Article

Genome sequencing broadens the range of contributing variants with clinical implications in schizophrenia.

Translational psychiatry - 1 Feb 2021

Mojarad Bahareh A, Yin Yue, Manshaei Roozbeh, Backstrom Ian, Costain Gregory, Heung Tracy, Merico Daniele, Marshall Christian R, Bassett Anne S, Yuen Ryan K C

Abstract excerpt

The range of genetic variation with potential clinical implications in schizophrenia, beyond rare copy number variants (CNVs), remains uncertain. We therefore analyzed genome sequencing data for 259 unrelated adults with schizophrenia from a well-characterized community-based cohort previously examined with chromosomal microarray for CNVs (none with 22q11.2 deletions). We analyzed these genomes for rare...

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PMID: 33526774
DOI: 10.1038/s41398-021-01211-2
PMCID: PMC7851385

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