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Article

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations.

Nature communications - 9 Sept 2021

Rees Elliott, Creeth Hugo D J, Hwu Hai-Gwo, Chen Wei J, Tsuang Ming, Glatt Stephen J, Rey Romain, Kirov George, Walters James T R, Holmans Peter, Owen Michael J, O'Donovan Michael C

Abstract excerpt

People with schizophrenia are enriched for rare coding variants in genes associated with neurodevelopmental disorders, particularly autism spectrum disorders and intellectual disability. However, it is unclear if the same changes to gene function that increase risk to neurodevelopmental disorders also do so for schizophrenia. Using data from 3444 schizophrenia trios and 37,488 neurodevelopmental disorder trios,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34504065
DOI: 10.1038/s41467-021-25532-4
PMCID: PMC8429694

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