Article
Genome-wide burden of deleterious coding variants increased in schizophrenia.
Nature communications - 9 Jul 2015
Loohuis Loes M Olde, Vorstman Jacob A S, Ori Anil P, Staats Kim A, Wang Tina, Richards Alexander L, Leonenko Ganna, Walters James T, DeYoung Joseph, Cantor Rita M, Ophoff Roel A
Abstract excerpt
Schizophrenia is a common complex disorder with polygenic inheritance. Here we show that by using an approach that compares the individual loads of rare variants in 1,042 schizophrenia cases and 961 controls, schizophrenia cases carry an increased burden of deleterious mutations. At a genome-wide level, our results implicate non-synonymous, splice site as well as stop-altering single-nucleotide variations...
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